多能外围质细胞产生上腺髓的神经内分泌细胞
Alessandro Furlan1, Vyacheslav Dyachuk2,3,4, Maria Eleni Kastriti5
1Unit of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden.
概括
来自外围神经的施万细胞前体 (SCP) 迁移形成上腺髓的染色细胞,挑战神经起源理论. 这一发现揭示了外围神经作为神经内分泌发育的干细胞.
科学领域:
- 神经内分泌学
- 发育生物学
- 干细胞生物学
背景情况:
- 上腺素是一种关键的压力激素,由上腺髓 (AM) 中的染色素细胞产生.
- 这些细胞传统上被认为仅来自神经细胞.
- 了解AM细胞的起源对于神经内分泌系统的发展至关重要.
研究的目的:
- 调查上腺细胞的细胞起源.
- 确定神经内分泌发育的替代干细胞来源.
- 阐明参与AM形成的发展途径.
主要方法:
- 追踪施万细胞前体的迁移和分化.
- 在细胞状态转换过程中分析基因表达模式.
- 研究外围神经作为干细胞的作用.
主要成果:
- 证实了大量的克罗马芬细胞来源于外围的施万细胞前体 (SCP).
- 这些SCP沿着神经迁移到上腺, 脱离并分化为细胞.
- 识别了对SCP进行染色体细胞分化的序列基因表达程序.
结论:
- 周围神经是神经内分泌系统发展的关键干细胞.
- 施瓦恩细胞前体是上腺髓色素细胞的主要来源.
- 这一发现重新定义了上腺的发育起源.
相关概念视频
Hormones of the Adrenal Glands
5.9K
Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and...
5.9K
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla
3.1K
The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...
3.1K
Glial Cells
95.6K
Overview
95.6K
Anatomy of the Adrenal Glands
5.3K
The adrenal or supra-renal glands, situated above the kidneys and aligned with the twelfth rib, are paired pyramid-shaped structures crucial for the body's stress response. During stress, these glands secrete hormones vital for adaptive physiological reactions.
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
These glands possess a distinctive yellow tinge due to the stored cholesterol and fatty acids required for hormone synthesis. They are encased in a fibrous capsule and cushioned by fat.
The adrenal gland comprises two distinct...
5.3K
Nervous Tissue: Glial Cells
7.5K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
7.5K
Differentiation of Common Myeloid Progenitor Cells
4.1K
Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
4.1K


