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  1. 首页
  3. 人类结直肠癌中的淋巴和远程转移的起源
  1. 首页
  3. 人类结直肠癌中的淋巴和远程转移的起源

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人类结直肠癌中的淋巴和远程转移的起源

Kamila Naxerova1,2, Johannes G Reiter3, Elena Brachtel4

  • 1Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. naxerova.kamila@mgh.harvard.edu.

Science (New York, N.Y.)
|July 8, 2017

在PubMed 上查看摘要

概括
此摘要是机器生成的。

癌症扩散到淋巴结并不总是导致远程转移. 在结直肠癌中,远程转移通常独立于原发瘤,而不仅仅来自淋巴结的扩散.

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科学领域:

  • 癌症学
  • 癌症生物学
  • 进化医学

背景情况:

  • 癌细胞从原发性瘤扩散到淋巴结与生存率低下有关.
  • 一个常见的模型表明淋巴结转移播种远程转移,证明了淋巴结在癌症分期 (TNM系统) 中的去除.

研究的目的:

  • 研究初级结直肠瘤,淋巴结转移和远程转移之间的进化关系.
  • 确定淋巴结转移是否是结直肠癌中远程转移的必要前体.

主要方法:

  • 分析了17名结直肠癌患者的213个档案活检样本.
  • 在超可变DNA区域中利用体变异来重建基因树.
  • 用高可靠性的基因分析来追踪转移的起源.

主要成果:

  • 在65%的病例中,淋巴和远程转移源于原始瘤内的独立子克隆.
  • 在35%的病例中,淋巴转移和远程转移在主瘤中具有共同的亚克隆起源.
  • 在结肠直肠癌中显示了淋巴转移和远程转移之间的两种不同的血统关系.

结论:

  • 淋巴结转移总是产生远程转移的现有模式并不适用于结直肠癌.
  • 结肠直肠癌转移可以遵循独立的进化轨迹,在很大一部分病例中,远程传播直接来自主瘤.
  • 研究结果表明,重新评估癌症阶段和针对淋巴结的治疗策略可能是合理的.