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小分子识别触发了DNA折叠和头利酶催化中的二次和三次相互作用

Jie Mao1, Chris DeSantis1, Dennis Bong1

  • 1Department of Chemistry and Biochemistry, The Ohio State University , 100 West 18th Avenue, Columbus, Ohio 43210, United States.

Journal of the American Chemical Society
|July 11, 2017
PubMed
概括

来自tris2-aminoethyl) amine (tren) 的新合成基架可以准并重新折叠特定的DNA/RNA结构. 这些化合物起到功能开关的作用,使得新型全性 рибо开关和小分子核酸复合物的设计成为可能.

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