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干扰素调节因子5通过减弱细胞形成来控制动脉样硬化病变中的死核形成

Anusha N Seneviratne1, Andreas Edsfeldt1, Jennifer E Cole1

  • 1From Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, United Kingdom (A.N.S., A.E., J.E.C., C.K., M.S., I.P., P.G., T.K., D.S., M.E.G., S.N.S., I.A.U., C.M.); Department of Bioengineering, Imperial College London, United Kingdom (A.N.S., R.K.); Experimental Cardiovascular Research Unit, Clinical Research Centre, Clinical Sciences Malmö, Lund University, Sweden (A.E., I.G.); Department of Cardiology, Skåne University Hospital, Lund/Malmö, Sweden (A.E., I.G.); and School of Engineering and Materials Science, Queen Mary University of London, United Kingdom (R.K.).

Circulation
|July 13, 2017
PubMed
概括

干扰素调节因子 (IRF) 5通过维持炎症性骨髓细胞和扩大的死核促进动脉样硬化. 在小鼠中删除IRF5改善了血细胞增生和减少了病变大小,这表明IRF5是治疗点.

关键词:
CD11c 其他IRF5 其他动脉样硬化细胞增生巨细胞

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