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可降解聚合物的可逆自组,在水中具有上临界溶液温度
Thomas Wolf1, Timo Rheinberger1, Johanna Simon1
1Max-Planck-Institut für Polymerforschung , Ackermannweg 10, 55128 Mainz, Germany.
Journal of the American Chemical Society
|July 22, 2017
概括
研究人员开发了第一种具有可调高临界相分离 (UCST) 行为的可降解聚合物. 这些智能聚合物自组装成纳米结构, 在更高的温度下膨胀或分解.
科学领域:
- 聚合物化学
- 材料科学
- 纳米技术
背景情况:
- 区块共聚物通过温度诱导的自我组装使智能纳米结构形成.
- 目前的系统主要使用不可降解的低临界溶液温度 (LCST) 段.
- 缺少可降解的上临界相分离 (UCST) 块共聚物,用于温度触发的拆卸.
研究的目的:
- 引入第一个明确的,可降解的块共聚物,表现出可调节的UCST行为.
- 探索它们如何自组合成纳米结构,
- 为了研究潜在应用的温度依赖的膨胀和拆卸.
主要方法:
- 对二氧化的有机催化离子环开放共聚化产生多酸.
- 提基基的修饰以引入悬挂式碳酸,使得聚合物具有热敏性.
- 在水中的UCST行为 (4371 °C) 和与PEG自组合成聚合体的特征.
主要成果:
- 成功合成了具有受控分子量和组成的可降解聚酸.
- 开发的非细胞毒性,热敏的聚合物,在水中显示可调节的UCST.
- 已证明可以自组装成具有狭窄尺寸分布的明确聚合体.
- 根据响应块观察到聚合体的温度依赖性胀或完全分解.
结论:
- 展示了第一个可降解的UCST块共聚物,为智能材料提供了一个新的平台.
- 这些聚合物能够创建响应温度变化的动态纳米结构.
- 开发的材料对需要控制膨胀或拆卸的应用具有前景,并有可能进行骨干水解.
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