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控制基于物种的皮质-运动神经连接
Zirong Gu1, John Kalambogias2,3, Shin Yoshioka1
1Division of Developmental Biology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, OH 45229, USA.
Science (New York, N.Y.)
|July 29, 2017
概括
通常通过Sema6D-PlexA1信号消除的小鼠的短暂皮质 - 运动神经连接可以维持到成年期,从而提高手动灵敏度. 特定物种的PlexA1调节影响了灵长类动物的精细运动控制进化.
科学领域:
- 神经科学
- 进化生物学
- 发育生物学
背景情况:
- 皮层-运动神经元 (CM) 连接对于精细运动控制至关重要,特别是在灵长类动物中.
- 哺乳动物皮质脊髓 (CS) 系统的发展和调节是理解运动技能演变的关键.
研究的目的:
- 研究短暂的CM连接在早期发育中的作用.
- 探索调节CM连接消除的分子机制.
- 了解CM连接在灵长类手工技能的进化意义.
主要方法:
- 使用的小鼠模型,包括PlexA1突变.
- 研究了Sema6D-PlexA1信号对CM连接的影响.
- 在运动皮层中分析基因表达模式 (PlexA1,FEZF2).
- 突变和野生类型小鼠之间的手术技巧比较.
主要成果:
- 在出生后早期的小鼠中发现过渡性CM连接,通常通过Sema6D-PlexA1信号消除.
- 突变的PlexA1小鼠保留了成年CM连接, 并显示了增强的手动灵巧.
- 在运动皮层PlexA1表达中发现了特定物种的差异,这些差异可能由高级灵长类动物的FEZF2介导元素调节.
结论:
- 暂时的CM连接在发动机发育中起作用,并且可以在实验中保持.
- 在小鼠中,Sema6D-PlexA1信号对于消除短暂的CM连接至关重要.
- 受FEZF2影响的PlexA1表达的物种依赖调节可能有助于灵长类动物的手工敏捷性和精细运动控制的进化.
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