相关实验视频

Updated: Feb 25, 2026

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase
11:57

Saccharomyces cerevisiae Models of Alzheimer's Disease to Screen Genes, Mutations, and Chemicals Affecting Amyloid Beta Production by γ-Secretase

Published on: June 24, 2025

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导致阿尔茨海默病的突变通过破坏γ-分泌酶-βn相互作用来改变Aβ长度

Maria Szaruga1, Bogdan Munteanu2, Sam Lismont1

  • 1KU Leuven-VIB Center for Brain & Disease Research, VIB, 3000 Leuven, Belgium; Department of Neurosciences, Leuven Institute for Neuroscience and Disease, KU Leuven, 3000 Leuven, Belgium.

Cell
|July 29, 2017
PubMed
概括

阿尔茨海默病的突变破坏了酶处理,导致更长的粉样β. 稳定这些相互作用可以防止阿尔茨海默病的进展.

关键词:
阿尔茨海默病粉样蛋白β粉样蛋白前体蛋白酶热活性这种药物蛋白质的热可变性γ-分泌酶

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