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Updated: Feb 25, 2026

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay
09:03

Parallel Interrogation of β-Arrestin2 Recruitment for Ligand Screening on a GPCR-Wide Scale using PRESTO-Tango Assay

Published on: March 10, 2020

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通过G蛋白结合受体识别阿雷斯的酸化代码

X Edward Zhou1, Yuanzheng He2, Parker W de Waal2

  • 1VARI-SIMM Center, Center for Structure and Function of Drug Targets, CAS-Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Laboratory of Structural Sciences, Center for Structural Biology and Drug Discovery, Van Andel Research Institute, Grand Rapids, MI 49503, USA.

Cell
|July 29, 2017
PubMed
概括

研究人员发现了化G蛋白结合受体 (GPCR) 如何与阿斯特林结合. 这一发现揭示了一种称为酸化代码的常见机制,用于阻止GPCRs的招募,影响细胞信号传输.

关键词:
一个GPCR土耳其在有偏差的信号药物发现膜蛋白质化代码红素

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