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Updated: Feb 25, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
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一种与五种血管疾病相关的基因变异是内甲素-1基因表达的远程调节者

Rajat M Gupta1, Joseph Hadaya2, Aditi Trehan2

  • 1Broad Institute of MIT and Harvard University, Cambridge, MA, USA; Cardiology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA USA; Center for Genomic Medicine, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Cell
|July 29, 2017
PubMed
概括

在PHACTR1基因 (rs9349379) 附近的一种常见的基因变异通过调节大动脉中的内甲蛋白1 (EDN1) 表达影响了五种血管疾病的风险. 这一发现突显了血管疾病发病的远端调节机制.

关键词:
其他国家心血管疾病冠状动脉疾病内皮细胞细胞内素-1表观遗传学基因增强元件全基因组关联研究高血压偏头痛疾病

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