相关实验视频

Updated: Feb 25, 2026

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter
06:59

Using Next Generation Sequencing to Identify Mutations Associated with Repair of a CAS9-induced Double Strand Break Near the CD4 Promoter

Published on: March 31, 2022

2.9K

聚类突变标记显示,容易发生错误的DNA修复将突变定位在活跃的基因上

Fran Supek1, Ben Lehner2

  • 1EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation (CRG), the Barcelona Institute of Science and Technology, 08003 Barcelona, Spain; Universitat Pompeu Fabra (UPF), 08003 Barcelona, Spain; Division of Electronics, Rudjer Boskovic Institute, 10000 Zagreb, Croatia.

Cell
|July 29, 2017
PubMed
概括

聚类突变提供了一个精确的指纹来识别突变过程. 这项研究揭示了与APOBEC活动,烟草吸烟以及各种癌症的DNA修复机制相关的特征.

关键词:
癌症基因组学表观遗传标记欧克罗马丁局部高突变不匹配的修复癌症基因一个核酸体变体转化DNA合成

更多相关视频

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

4.1K
Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells11:06

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

13.6K

相关概念视频

Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
6.8K
Mismatch Repair01:36

Mismatch Repair

Overview
44.1K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
5.4K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
41.2K
Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
34.3K
Overview of DNA Repair02:25

Overview of DNA Repair

10.1K