慢性拒绝心脏移植与增加的淋巴流和细胞流通有关
Lindsey A Edwards1, Anna K Nowocin2, Nazila V Jafari2
1MRC Centre for Transplantation, King's College London, Guy's Hospital, United Kingdom (L.A.E., A.K.N., N.V.J., L.L.M., K.B., A.S., C.L., A.M., W.W.) wilson.wong@kcl.ac.uk lindsey.edwards@kcl.ac.uk.
Circulation
|August 5, 2017
概括
心脏移植后的慢性排斥会增加淋巴流,可能促进免疫反应和移植损失. 这项研究量化了小鼠模型中的淋巴流, 揭示了它与免疫细胞贩运和血管病的联系.
科学领域:
- 免疫学
- 移植生物学
- 血管生物学
背景情况:
- 心脏移植是治疗晚期心脏病的重要方法.
- 慢性排斥导致心脏移植血管病变,是移植损失的主要原因.
- 淋巴系统在免疫和移植排斥中的作用尚不完全理解.
研究的目的:
- 研究心脏移植后的淋巴血管功能.
- 在慢性排斥的小鼠模型中量化淋巴流量.
主要方法:
- 在小鼠模型中进行异位心脏移植.
- 单光子发射计算机断层扫描/计算机断层扫描用于测量淋巴流量指数.
主要成果:
- 与对照组相比,移植心脏的淋巴流量指数增加.
- 增加的淋巴流与增加的供体细胞流向淋巴结相关.
- 淋巴血管面积增加和免疫细胞透 (CD4+,CD8+T细胞,CD68+巨细胞) 在移植中.
结论:
- 慢性排斥会增加从供体移植到淋巴结的淋巴流量.
- 淋巴流量增加可能会增强免疫细胞的流通,导致非免疫性和心脏移植性血管病变.
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