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对于心肌细胞平衡和过度增生,需要基因组甲基转移酶G9a

Roberto Papait1, Simone Serio2, Christina Pagiatakis2

  • 1From Department of Cardiovascular Medicine, Humanitas Research Hospital, Rozzano, Milan, Italy (R.P., S.S., C.P., F.R., P.C., N.S., M. Miragoli, G.C.); Genetic and Biomedical Research Institute, National Research Council of Italy, Rozzano, Milan, Italy (R.P., F.R., P.C., N.S., G.C.); Humanitas University, Rozzano, Milan, Italy (M. Mazzola, G.C.); School of Medicine, University of Verona, Italy (M. Mazzola); and Department of Medicine and Surgery, University of Parma, Italy (M. Miragoli). roberto.papait@humanitasresearch.it gianluigi.condorelli@hunimed.eu.

Circulation
|August 6, 2017
PubMed
概括

基因组甲基转移酶G9a对成人心脏功能至关重要,因为它抑制维持心肌细胞平衡的基因并促进心脏缩. 这种表观遗传调节剂为心脏病提供了潜在的治疗点.

关键词:
鼠标的 EHMT2 蛋白鼠标的MEF2C蛋白表观遗传学心脏衰竭不同染色素基斯甲基化过度增长

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