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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
帕金森病患者每周使用一次的埃克森与安慰剂:随机,双盲,安慰剂对照试验
Dilan Athauda1, Kate Maclagan2, Simon S Skene2
1Sobell Department of Motor Neuroscience, University College London Institute of Neurology and the National Hospital for Neurology and Neurosurgery, London, UK.
在停止治疗后的几周内,exenatide 改善了帕金森病患者的运动功能. 这种GLP-1激动剂对长期控制帕金森病的症状具有前景.
科学领域:
- 神经科学
- 临床药理学
背景情况:
- 作为GLP- 1受体激动剂的exenatide在帕金森病模型中表现出临床前的神经保护作用.
- 研究了exenatide在帕金森病患者的潜在临床疗效.
研究的目的:
- 评估exenatide在改善中度帕金森病患者的运动功能的有效性.
- 为了评估治疗期之后的长期效应.
主要方法:
- 一个单中心,随机,双盲,安慰剂对照试验,涉及62名中度帕金森病患者.
- 患者每周接受皮下施用exenatide (2 mg) 或安慰剂,持续48周,随后进行12周的洗.
- 主要结果:在停止药物治疗的60周后,MDS- UPDRS运动分级分数的差异.
主要成果:
- 在MDS- UPDRS运动分量表中,exenatide组的平均改善为1. 0分,而安慰剂组的平均改善为2. 1分.
- 在60周后,调整后的平均差异为-3. 5点 (p=0. 0318),有利于埃塞纳提德,表明持续的运动改善.
- 常见的不良事件包括注射部位反应和胃肠道症状;没有报告与研究相关的严重不良事件.
结论:
- 在帕金森病患者中,埃克塞纳提德对非药物治疗的运动分数产生了积极和持续的影响.
- 这项研究表明,exenatide是帕金森病的潜在新疗法,需要在更长的试验中进行进一步的研究.
- 需要进行进一步的研究,以确定埃塞纳提德是否会影响疾病的病理生理学,或者只能提供长期的症状缓解.
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