人类的生殖和健康:一个进化观点
Grazyna Jasienska1, Richard G Bribiescas2, Anne-Sofie Furberg3
1Department of Environmental Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland.
Lancet (London, England)
|August 10, 2017
概括
生命史理论将生殖投资与疾病风险和寿命联系起来. 了解生态因素如何影响生殖特征可以为非传染性疾病的公共卫生策略提供信息.
科学领域:
- 进化生物学
- 生殖内分泌学
- 公共卫生
背景情况:
- 生命史理论认为生殖投资会影响疾病风险和寿命.
- 生殖特征表现出可塑性,受营养和活动等生态因素的影响.
- 在一生中发生的荷尔蒙变化会影响疾病的易感性.
研究的目的:
- 从进化角度探讨生殖投资与非传染性疾病风险之间的关系.
- 突出表型可塑性在生殖特征变异中的作用.
- 提供对荷尔蒙敏感疾病的公共卫生干预信息.
主要方法:
- 对生命历史理论和进化生物学原理的审查.
- 对生殖特征,环境因素和疾病发生率之间的关联进行分析.
- 综合当前对荷尔蒙对健康的影响的理解.
主要成果:
- 增加生殖投资与某些癌症,糖尿病和心血管疾病的风险增加有关.
- 生态条件显著调节生殖激素度和特征.
- 生育率下降与激素敏感癌症的发病率上升有关.
结论:
- 生殖生物学的进化框架可以提高公共卫生策略.
- 控制影响生殖功能的环境和生活方式因素可能会减轻疾病风险.
- 需要进一步研究生殖,环境和健康的相互作用.
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