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Imaging Biological Samples with Optical Microscopy01:18

Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
In optical microscopy, the specimen to be viewed is placed on a glass slide and clipped on the stage...
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Synthesis and Operation of Fluorescent-core Microcavities for Refractometric Sensing
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异常点可以在光学微腔中增强传感

Weijian Chen1, Şahin Kaya Özdemir1, Guangming Zhao1

  • 1Department of Electrical and Systems Engineering, Washington University, St Louis, Missouri 63130, USA.

Nature
|August 11, 2017
PubMed
概括

研究人员使用特殊点提高了微腔传感器的灵敏度. 这种方法可以放大来自纳米物体的信号,为先进的传感应用提供前所未有的检测能力.

科学领域:

  • 光子学和光学传感
  • 量子力学和非赫尔密斯物理学

背景情况:

  • 光学微空洞增强了感应应用中的光物质相互作用.
  • 传统的微腔传感器通过共振转移或线宽变化来检测干扰.
  • 现有的方法对于检测纳米级物体的灵敏度有局限性.

研究的目的:

  • 通过使用特殊点 (EP) 来提高微空洞的灵敏度来展示一种新型的传感方案.
  • 探索非赫尔密斯变异的潜力以改善纳米级感应.
  • 为了实现比传统的传感系统更高的灵敏度.

主要方法:

  • 使用低声画廊模式的微 toroid 腔.
  • 使用两个纳米级散射器来精确调整微腔到一个特殊的点.
  • 引入一个纳米级目标物体进入消失的领域来扰乱系统.
  • 测量了所产生的频率分裂.

主要成果:

  • 证明频率分裂是EP附近扰动强度的平方根.
  • 与传统方法相比,观察到较小的频率分裂.
  • 通过纳米级物体成功扰乱了系统的特殊点.

结论:

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  • 特殊的点增强灵敏性为基于微腔的传感器提供了一个新范式.
  • 这种方法使得检测纳米级物体的灵敏度空前.
  • 这为下一代传感器铺平了道路,