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一个被改造的子突变导致的社会行为和神经发育缺陷

Hua Yan¹, Comzit Opachaloemphan², Giacomo Mancini³

¹Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University School of Medicine, New York, NY 10016, USA.

|August 13, 2017

概括

这项研究揭示了共受体对的嗅觉,生殖生理和社会行为至关重要. 失去Orco功能会损害天线叶的发育, 建立Harpegnathos作为研究社会复杂性的模型.

科学领域:

神经伦理学
遗传学
昆虫的社会行为

背景情况:

在复杂的社会行为中,
嗅觉受体 (ORs) 是这种沟通的关键,
在中进行的遗传研究是有限的,除了在Harpegnathos saltator中,工人可以成为游戏门.

研究的目的:

为了研究Harpegnathos中的Orco共受体的功能.
探索兽人突变对嗅觉,生理和社会行为的影响.
建立哈尔佩格纳托斯盐人作为社会化的遗传模型.

主要方法:

用CRISPR-Cas9基因编辑在orco基因中产生生殖基因突变.
在突变中评估了嗅觉感知,生殖生理和社会行为可塑性.
在OR功能的背景下检查了天线叶的发育.

主要成果:

这种突变严重影响了嗅觉,生殖生理和社会行为.
失去了鱼的功能也阻碍了叶的发展.
这突显了Orco在气味接收之外的新角色.

结论:

在生物学中扮演着多方面的角色, 不仅影响嗅觉,
哈尔佩格纳托斯鱼的遗传能力与鱼的多样性功能相结合, 使它成为一个强大的模型生物.
这项研究提供了对复杂社会性基因和发展基础的新见解.

关键词:

关于CRISPR的研究哈尔佩格纳托斯的鱼一个鱼一个一种社会昆虫体神经发育气味受体嗅觉受体神经元铁激素复制社会行为

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In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.