神经可控制的社会行为和种姓认同
Janko Gospocic1, Emily J Shields2, Karl M Glastad1
1Epigenetics Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Cell and Developmental Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Cell
|August 13, 2017
概括
神经可调节昆虫的社会行为. 它的低调使得工人成为繁殖的游戏门, 而它的存在则促进了类似工人的行为.
科学领域:
- 神经伦理学
- 昆虫的社会行为
- 基因调节
背景情况:
- 尽管有共同的基因组,但社会昆虫表现出不同的行为.
- 了解种姓特异性基因调控是社会昆虫行为的关键.
- 哈佩格纳托斯的鱼工人可以过渡到繁殖的游戏门状态.
研究的目的:
- 研究哈尔佩格纳托斯鱼的种姓特异性行为的分子机制.
- 确定关键的神经涉到工人到玩家的过渡.
- 确定corazonin在调节社会昆虫种姓身份和行为的作用.
主要方法:
- 在从工人到玩家的转换过程中进行大脑转录组分析.
- 测量卡拉佐宁神经的水平.
- 在过渡性中进行神经注射实验.
- 测量狩猎,决斗和产卵的行为测试.
主要成果:
- 在从工人到玩家的过渡过程中,corazonin神经的调节下降.
- 科拉佐宁在不同物种的工人中被优先表达.
- 卡拉佐宁的注射抑制了玩家门的行为,
- 科拉佐宁注射抑制了大脑中的维特洛根因表达.
结论:
- 在社会昆虫中,corazonin是种姓认同和行为的关键调节者.
- 卡拉佐宁的差异表达是驱动行为可塑性的关键分子机制.
- 这项研究提供了社会组织的神经生物学基础的见解.
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