相关实验视频
Updated: Feb 24, 2026
14:54
A Controlled Mouse Model for Neonatal Polymicrobial Sepsis
Published on: January 27, 2019
11.9K
印度农村婴儿中预防败血症的随机协生试验
Pinaki Panigrahi1,2, Sailajanandan Parida3, Nimai C Nanda4
1Department of Epidemiology, Center for Global Health and Development, College of Public Health, University of Nebraska Medical Center, Nebraska, USA.
Nature
|August 17, 2017
概括
一种口服的共生药物含有植物菌和果糖在印度新生儿中显著降低了败血症和死亡率. 这种干预措施为发展中国家新生儿感染提供了有前途的预防策略.
科学领域:
- 新生儿健康
- 微生物组研究
- 预防传染病
背景情况:
- 新生儿败血症每年造成100万人死亡, 主要发生在发展中国家.
- 目前婴儿败血症的预防方法不足.
- 口服共生药是一种潜在的新干预措施.
研究的目的:
- 评估一种口服共生菌 (Lactobacillus plantarum加上果糖) 在印度农村新生儿中预防败血症和死亡的有效性.
- 评估共生补充剂对培养阳性和培养阴性败血症和下呼吸道感染的影响.
主要方法:
- 进行了一项随机,双盲,安慰剂对照的试验.
- 招募了4556名符合条件的新生儿,并对其进行了60天的监测.
- 干预组接受了口服共生制剂.
主要成果:
- 在共生组中观察到结合性败血症和死亡的结果显著降低 (风险比为0. 60).
- 协生干预还导致培养阳性败血症,培养阴性败血症和下呼吸道感染的显著减少.
- 两组的死亡率都很低,但支持共生手臂.
结论:
- 口服配合生物补充剂Lactobacillus plantarum ATCC-202195和果糖在预防新生儿败血症和死亡方面是有效的.
- 在资源有限的环境中,这种干预措施有很大的潜力减少新生儿感染的负担.
- 在发展中国家, 协生菌提供了可行且易于使用的方法来改善婴儿生存率.
相关概念视频
01:22Healthcare Associated Infections II: Preventive Measures
4.4K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
4.4K
01:17Drugs for Treatment of Diarrhea-Predominant IBS
783
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
783