胃上皮干细胞和腺体平衡的调节
Michael Sigal1,2,3, Catriona Y Logan4, Marta Kapalczynska1,2
1Department of Molecular Biology, Max Planck Institute for Infection Biology, 10117 Berlin, Germany.
Nature
|August 17, 2017
概括
胃干细胞的循环由Wnt信号和R-spondin 3进行调节. 杆菌感染会扩大干细胞种群,导致胃上皮再生和增生.
科学领域:
- 胃肠病学
- 干细胞生物学
- 复原医学
背景情况:
- 胃上皮的再生依赖于长寿的干细胞,但调节机制尚不清楚.
- Wnt信号对于干细胞的识别和上皮再生至关重要.
- 杆菌感染激活胃干细胞,增加上皮细胞的循环.
研究的目的:
- 研究胃干细胞循环的调节.
- 阐明Wnt信号传递和胃层因子在胃再生中的作用.
- 了解Helicobacter pylori对胃干细胞动态的影响.
主要方法:
- 在胃腺中分析Wnt信号标记物 (Axin2) 和干细胞标记物 (Lgr5).
- 在胃肌纤维细胞中研究R-spondin 3的表达和功能.
- 在R-spondin和H. pylori感染后对干细胞增殖和腺体再生进行评估.
主要成果:
- 由Axin2标记的Wnt信号局部化到干细胞中.
- Lgr5+干细胞和相邻的Lgr5细胞表达Axin2并有助于腺体的重新填充.
- 肌纤维细胞产生的Stromal R-spondin 3对于Axin2和Lgr5的表达至关重要.
- 甲状腺菌感染会增加肌体R- 脊柱蛋白的调节,扩大Axin2+细胞池并导致腺体增生.
结论:
- 通过R-spondin 3, 控制胃上皮干细胞的动态.
- 这种相互作用调节上皮再生并保持组织完整性.
- 杆菌利用这种机制,导致过度增殖和过度增生.
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