现场结构,功能和收缩注入系统的演变
Désirée Böck1, João M Medeiros1, Han-Fei Tsao2
1Institute of Molecular Biology and Biophysics, Eidgenössische Technische Hochschule Zürich, CH-8093 Zürich, Switzerland.
概括
细菌中的6型分泌系统 (T6SS) 使用收缩注射系统进行细胞间相互作用. 研究人员揭示了它的现场结构和发射机制,表明它在宿主相互作用和T6SS多样性中发挥了更广泛的作用.
科学领域:
- 微生物学
- 结构生物学
- 细胞生物学
背景情况:
- 类型6分泌系统 (T6SS) 是一种缩的注射机器,可以调解细菌细胞之间的相互作用.
- 与细胞外系统不同,T6SS是细胞内和膜相关的,类似于细菌尾结构.
研究的目的:
- 为了阐明T6SS在*Amoebophilus asiaticus*中的实地结构和功能.
- 了解T6SS在燃烧周期中的构造变化和组装.
主要方法:
- 用冷聚焦的离子束削
- 电子冷图
- 功能测试
- 进化序列分析
主要成果:
- T6SS架构包括三个模块:收缩管,底板和.
- 在发射时观察到所有模块的形状变化.
- 侧面基板相互作用促进了T6SS的六角阵列形成.
- 该系统与宿主膜相互作用,并可能有助于细胞逃逸.
结论:
- 这项研究提供了细菌T6SS的详细结构和功能理解.
- T6SS在细菌中可能比以前更为普遍.
- 这些发现为探索T6SS多样性和机制提供了基础.
相关概念视频
Convolution: Math, Graphics, and Discrete Signals
1.3K
In any LTI (Linear Time-Invariant) system, the convolution of two signals is denoted using a convolution operator, assuming all initial conditions are zero. The convolution integral can be divided into two parts: the zero-input or natural response and the zero-state or forced response, with t0 indicating the initial time.
To simplify the convolution integral, it is assumed that both the input signal and impulse response are zero for negative time values. The graphical convolution process...
To simplify the convolution integral, it is assumed that both the input signal and impulse response are zero for negative time values. The graphical convolution process...
1.3K
Reconstruction of Signal using Interpolation
920
Signal processing techniques are essential for accurately converting continuous signals to digital formats and vice versa. When a continuous signal is sampled with a period T, the resulting sampled signal exhibits replicas of the original spectrum in the frequency domain, spaced at intervals equal to the sampling frequency. To handle this sampled signal, a zero-order hold method can be applied, which creates a piecewise constant signal by retaining each sample's value until the next...
920
Downsampling
872
When considering a sampled sequence with zero values between sampling instants, one can replace it by taking every N-th value of the sequence. At these integer multiples of N, the original and sampled sequences coincide. This process, known as decimation, involves extracting every N-th sample from a sequence, thereby creating a more efficient sequence.
The Fourier transform of the decimated sequence reveals a combination of scaled and shifted versions of the original spectrum. This...
The Fourier transform of the decimated sequence reveals a combination of scaled and shifted versions of the original spectrum. This...
872
Upsampling
745
Managing signal sampling rates is essential in digital signal processing to maintain signal integrity. A decimated signal, characterized by a reduced frequency range due to its lower sampling rate, can be upsampled by inserting zeros between each sample. This upsampling process expands the original spectrum and introduces repeated spectral replicas at intervals dictated by the new Nyquist frequency. To refine this zero-inserted sequence, it is passed through a lowpass filter with a cutoff...
745
Properties of the z-Transform I
807
The z-transform is a fundamental tool in digital signal processing, enabling the analysis of discrete-time systems through its various properties. It is an invaluable tool for analyzing discrete-time systems, offering a range of properties that simplify complex signal manipulations. One fundamental property is linearity. For any two discrete-time signals, the z-transform of their linear combination equals the same linear combination of their individual z-transforms. This property is essential...
807
Indefinite Integrals
235
The water inflow rate into a storage tank is not constant but increases over time. Initially, the pump delivers water at a rate of 5 L/min. However, the inflow rate increases by 2 L/min for each additional minute due to rising pressure or system adjustments. This scenario can be described mathematically by a linear function:It is necessary to integrate the inflow rate function to measure the total volume of water added to the tank over time. The total water volume V(t) is obtained by performing...
235


