通过神经前体衍生的类蛋白进行介导
Elizabeth Y Qin1, Dominique D Cooper1, Keene L Abbott2
1Department of Neurology, Stanford University, Palo Alto, CA 94305, USA.
Cell
|August 22, 2017
概括
质瘤细胞通过从神经前体细胞 (NPC) 接收信号扩散到大脑的腹腔下区域 (SVZ). 向蛋白质和它的合作伙伴可能会阻止这种入侵.
科学领域:
- 神经科学
- 癌症学
- 细胞生物学
背景情况:
- 腹腔下区域 (SVZ) 是儿童和成年患者质瘤扩散的常见部位.
- 精确的细胞和分子机制驱动SVZ的质瘤殖民仍然在很大程度上未知.
研究的目的:
- 为了阐明质瘤细胞侵入SVZ的机制.
- 确定潜在的治疗点,以限制质瘤扩散到SVZ.
主要方法:
- 神经前体细胞 (NPC) - 质瘤细胞通信的分析.
- 生物化学,蛋白质和功能测试以确定分泌的因素.
- 在体内使用小鼠模型进行类蛋白倒置研究.
- 对质瘤Rho/ROCK信号通路的研究.
主要成果:
- 它们分泌化学吸引剂信号, 促进质瘤细胞向SVZ转移.
- 与SPARC/SPARCL1和HSP90B一起,类蛋白调解这种化学吸引作用.
- 在SVZ中显著减少质瘤的侵袭.
- 类蛋白激活了质瘤Rho/ ROCK信号,而ROCK抑制降低了侵入性.
结论:
- 质瘤细胞侵入SVZ是由NPC和质瘤细胞之间的通信驱动的.
- 类蛋白是质瘤细胞对SVZ的化学吸引的一个关键媒介.
- NPC:质瘤相互作用和质蛋白是抑制质瘤侵袭的潜在治疗点.
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