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分子和电路动态识别自上而下的神经机制来抑制寻求奖励

Christina K Kim¹, Li Ye², Joshua H Jennings³

¹Neurosciences Program, Stanford University, Stanford, CA, 94305, USA.

|August 22, 2017

概括

研究人员发现大脑中特定的神经通路控制着寻求或抑制寻求奖励的行为, 这一发现为调节行为和潜在的治疗目标提供了洞察力.

科学领域:

神经科学
行为科学

背景情况:

追求奖励的行为对于生存至关重要,
中间前额皮层 (mPFC) 参与抑制奖励寻求,但其神经回路尚未完全理解.

研究的目的:

阐明mPFC调节奖励行为的神经机制.
识别特定的神经元群体和参与抑制奖励寻求的途径.

主要方法:

在动物中使用2光子Ca2+成像和活动依赖标记.
研究了表面的mPFC投射到内核 (NAc) 的一个子场.

主要成果:

确定了对NAc神经元的表面mPFC投射的特定子集,这些神经元编码了启动或抑制奖励的决定.
这些神经元的不同亚群被发现能够抑制奖励寻求.
这些mPFC-to-NAc投影具有独特的分子遗传和微电路特征.

结论:

这项研究揭示了一个关键的神经回路来调节追求奖励的行为.
已识别的mPFC-NAc途径为理解和潜在治疗行为障碍提供了细胞和解剖目标.

关键词:

2光子Ca2+) 成像取决于活动的标签中部前额皮层体核视觉遗传学在寻求奖励腹部的顶部区域

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