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Updated: Feb 24, 2026

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甘西克洛维尔对临床临床试验中的细胞巨病毒阳性成年人IL-6水平的影响

Ajit P Limaye1, Renee D Stapleton2, Lili Peng3

  • 1Division of Allergy and Infectious Diseases, University of Washington, Seattle.

JAMA
|August 23, 2017
PubMed
概括

甘西克洛维尔预防并没有降低患有细胞巨病毒 (CMV) 严重疾病的成年人中的干白素-6 (IL-6) 水平. 虽然CMV的活性降低了,但常规使用甘西克洛维尔治疗败血症不支持.

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Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
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