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通过生物化dCas9捕获染色体相互作用

Xin Liu1, Yuannyu Zhang1, Yong Chen2

  • 1Children's Medical Center Research Institute, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Cell
|August 26, 2017
PubMed
概括

研究人员开发了一种新的CRISPR亲和性净化在位调节元件 (CAPTURE) 方法,以识别特定基因组位置的未知蛋白质复合体和DNA相互作用. 这种方法揭示了 cis 调节元件如何控制发育和疾病中的基因表达.

关键词:
在CRISPR/Cas9中在DNA循环中生物化染色体其他监管要素增强剂蛋白质组学超级增强剂

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