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相关概念视频

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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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相关实验视频

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A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
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重编程增强剂以驱动转移

Raul Mostoslavsky1, Nabeel Bardeesy2

  • 1The Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA; Massachusetts General Hospital Center for Regenerative Medicine, Harvard Medical School, Boston, MA 02114, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.

Cell
|August 26, 2017
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概括

胰腺癌转移包括Foxa1的大规模增强剂重编程. 这种转录因子激活了早期的内皮干细胞程序,促使瘤细胞扩散.

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科学领域:

  • 癌症学
  • 分子生物学
  • 遗传学

背景情况:

  • 在初级瘤中获得的分子变化可以驱动转移过程.
  • 癌细胞的转移是一个复杂的过程,

研究的目的:

  • 研究胰腺癌转移的分子机制.
  • 确定参与癌细胞传播的关键转录因子和调控途径.

主要方法:

  • 在胰腺癌中增强器重编程的分析.
  • 研究转录因子Foxa1的作用.
  • 使用分子测试识别激活的转录程序.

主要成果:

  • 罗和其他人. 表明转移性胰腺癌具有大规模的增强剂重编程.
  • 在这个重编程过程中,转录因子Foxa1起着至关重要的作用.
  • 确定了早期内皮干细胞转录程序的Foxa1激活.

结论:

  • 由Foxa1主导的增强剂重编程是胰腺癌转移的关键驱动因素.
  • 针对Foxa1或内皮干细胞计划可能为胰腺癌提供治疗策略.