通过中的生物脂质支架进行应力传播
Camilo Aponte-Santamaría1,2,3, Jan Brunken4, Frauke Gräter1,2
1Molecular Biomechanics Group, Heidelberg Institute for Theoretical Studies , 69118 Heidelberg, Germany.
Journal of the American Chemical Society
|August 31, 2017
概括
机械应力脉冲通过脂质双层迅速传播,每秒行驶数公里. 这些超快的信号在缩之前会传输几十纳米, 作为细胞膜中的快速信号传递机制.
科学领域:
- 生物物理
- 细胞生物学
- 分子动力学
背景情况:
- 膜张力对于细胞功能至关重要.
- 了解脂质双层中的机械应力传播是必不可少的.
研究的目的:
- 研究生物脂质双层中的机械应力脉冲传播的速度和距离.
- 阐明应激传播的机制及其在细胞信号传递中的潜在作用.
主要方法:
- 粗的分子动力学模拟.
- 所有原子分子动力学模拟.
- 应力脉冲速度,衰减和分散关系的分析.
主要成果:
- 观察到的纳米宽的应力脉冲以~1.4 nm/s (km/s) 的纵向传播.
- 预测的脉冲衰减时间为几十比秒,允许在几十纳米内传播.
- 分散关系与连续粘弹性模型相一致.
结论:
- 局部化机械应力通过脂质双层有效和快速传播.
- 这种超快的应力传播可以作为拥挤的生物膜中的信号机制.
- 这些发现与连续性粘弹性波传播理论一致.
相关概念视频
Biosynthesis of Lipids
729
Microbial membranes exhibit remarkable diversity in lipid composition, reflecting evolutionary adaptations to various environmental conditions. The three domains of life—Bacteria, Archaea, and Eukarya—synthesize membrane lipids through distinct biosynthetic pathways, leading to fundamental structural differences that impact membrane stability, function, and adaptability.Fatty Acid-Based Lipids in Bacteria and EukaryaBacteria and eukaryotes share a common fatty acid biosynthesis...
729
Asymmetric Lipid Bilayer
10.4K
Biological membranes show uneven distribution of different types of lipids in the inner and outer layers, resulting in transverse asymmetric membranes. The treatment of the erythrocyte membrane with the enzyme phospholipase confirmed the asymmetric nature of the lipid bilayer. The enzyme hydrolyzes lipids into fatty acids and hydrophilic groups. The phospholipase acts only on the outer layer of the membrane, while the inner layer remains intact. The phospholipase treatment resulted in 80%...
10.4K
Assembly of the Lipid Bilayer in the ER
4.3K
Biological membranes are more than just a barrier separating cell cytoplasm from the outside environment. They are highly dynamic and help maintain the integrity and physiological stability of the cells as well as membrane-bound organelles. Membranes also play vital roles in cell-to-cell and intracellular communication.
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
A large chunk of any biological membrane is composed of phospholipids. These lipids have a heterogeneous distribution across different subcellular organelles and even between...
4.3K


