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丹麦男性的血管疾病人口查和干预 (VIVA):随机对照试验
Jes S Lindholt1, Rikke Søgaard2
1Department of Cardiothoracic and Vascular Surgery, Odense University Hospital, Odense, Denmark; Vascular Research Unit, Viborg Hospital, Viborg, Denmark.
Lancet (London, England)
|September 2, 2017
概括
对腹腔大动脉瘤,外周动脉疾病和高血压的综合查显著降低了全因死亡率. 这种主要由药物治疗启动的方法为改善人口健康提供了一种新的策略.
科学领域:
- 心血管疾病研究
- 公共卫生查计划
- 临床试验方法
背景情况:
- 腹腔大动脉瘤是人口查的唯一心血管疾病.
- 这项研究研究了查和干预腹腔大动脉瘤,外周动脉疾病和高血压的综合影响.
研究的目的:
- 评估腹腔大动脉动脉瘤,外周动脉疾病和高血压综合查方案的有效性.
- 评估这种综合查对所有原因死亡率的影响.
主要方法:
- 一项随机对照试验将65至74岁的男性分为查或不进行查.
- 主要结局是随机化后5年评估的全因死亡率.
- 患有确定的疾病的参与者获得确认,开始治疗或转诊.
主要成果:
- 共有50,156名参与者被随机选择.
- 查组显示所有原因死亡率显著降低 (HR 0. 93, p=0. 01).
- 在糖尿病,脑内出血,功能衰竭,癌症或手术后30天死亡率方面没有显著差异.
结论:
- 这些血管疾病的综合查显著降低了死亡风险.
- 观察到的好处主要归因于药物治疗的开始.
- 卫生政策应该考虑实施这种综合查方法.
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