在刺激性肠综合征中异常的阴道功能
Lancet (London, England)
|August 29, 1987
概括
自主神经系统功能障碍在刺激性肠综合征 (IBS) 患者中很常见,影响肠道和心脏功能. 这些神经系统异常可能解释常见的IBS症状,如胃食道逆流和运动问题.
科学领域:
- 胃肠病学 胃肠病学
- 自主神经科学 自主神经科学
- 临床医学 临床医学
背景情况:
- 刺激性肠综合征 (IBS) 是一种常见的功能性胃肠疾病.
- 自主神经系统 (ANS) 功能障碍越来越被认为是IBS病理生理学的潜在贡献者.
- 了解ANS参与对于开发向疗法至关重要.
研究的目的:
- 调查IBS患者的食和心脏自主神经功能.
- 为了确定IBS中自主功能障碍的患病率.
- 探索自主功能障碍和胃肠道症状或发现之间的关系.
主要方法:
- 在25名IBS患者和25名对照组中,评估了阴道介导的食道关节下部压力反应对腹部压缩的反应.
- 在23名IBS患者中,使用胰岛素诱导的低血糖和五素刺激试验评估了管功能.
- 在23名IBS患者的深呼吸期间测量脉率变化.
- 自主功能测试结果与内镜检测结果 (食管炎) 和胃食管逆流 (pH监测) 相关联.
主要成果:
- 与对照组相比,25名IBS患者中的13人显示,阴道介导下消化管关节压力的增加减少.
- 在23名IBS患者中,在7名患者中观察到不正常的虚静脉功能.
- 在23名IBS患者中,在6名患者中发现了深呼吸的脉冲率变化降低.
- 自主测试异常与食道炎或胃食道逆流没有很强的相关性.
结论:
- 在IBS患者中,自主神经反射异常很普遍.
- 这些自主功能障碍可能导致IBS中胃食道逆流的频繁发生.
- 自主神经系统功能障碍可能在IBS特征的胃肠道运动障碍中起作用.
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