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Updated: Feb 23, 2026

Author Spotlight: Establishing a New Fluorescence-Based Protocol for In Vivo Mitochondrial Morphology Analysis in Parkinson's Disease
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多巴胺氧化在帕金森病中调解线粒体和溶酶体功能障碍

Lena F Burbulla1,2, Pingping Song1, Joseph R Mazzulli1,2

  • 1Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.

Science (New York, N.Y.)
|September 9, 2017
PubMed
概括

线粒体氧化应激会导致多巴胺氧化,在帕金森病 (PD) 人类神经元中将线粒体和 lysosomal 功能障碍联系起来. 这一连串涉及氧化多巴胺和降低的葡萄糖大脑酶,驱动PD的神经退行.

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