淋巴增殖异常与转基因小鼠中Ty-1抗原的不适当表达有关
S Chen1, F Botteri, H van der Putten
1Cancer Biology and Gene Expression Laboratories, Salk Institute, San Diego, California 92138.
Cell
|October 9, 1987
概括
研究人员创造了转基因小鼠来研究Thy-1抗原,一种细胞表面蛋白质. 这些小鼠患有淋巴细胞增生症,这表明Thy-1
科学领域:
- 免疫学 免疫学 免疫学
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
背景情况:
- thy-1抗原是一种细胞表面糖蛋白,在T淋巴细胞,神经元和造血干细胞上发现.
- 它在造血细胞分化中的确切功能在很大程度上是未知的.
研究的目的:
- 为了研究Thy-1抗原在造血细胞分化中的作用.
- 探索在淋巴细胞发育过程中改变Thy-1表达模式的后果.
主要方法:
- 转基因小鼠的产生,这些小鼠携带了混合Thy-1基因 (Thy-1.2/E mu) 与免疫球蛋白重链增强剂 (E mu).
- 在各种血液细胞群和组织中分析Thy-1抗原表达模式.
- 转基因小鼠中淋巴状组织的表型特征.
主要成果:
- 转基因小鼠在成熟的B淋巴细胞及其祖先上表现出Thy-1.2抗原的表达.
- 观察到一种遗传性淋巴细胞增生症,其特征是骨髓和淋巴结中大量积累Thy-1.2抗原.
- 显而易见的是Thy-1基因表达的不适当的发育调节.
结论:
- Thy-1抗原可能在调节淋巴细胞原生细胞激活和分化方面发挥关键作用.
- 改变Thy-1表达可能导致发育异常,如淋巴细胞增生.
- 进一步研究Thy-1在早期淋巴细胞发育中的功能是有必要的.
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