在精神残疾人医院的护士中对乙型肝炎疫苗接种的经验
E A Follett1, I S Symington, M G Cameron
1Regional Virus Laboratory, Ruchill Hospital, Glasgow.
Lancet (London, England)
|September 26, 1987
概括
医院工作人员接种乙型肝炎疫苗显示出高抗体反应,但随着时间的推移, titre 降低. 对一些人来说,增强剂量是有效的,因此需要召回系统以获得持续的保护.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 乙型肝炎病毒 (HBV) 感染在医疗机构构成风险,尤其是与患者直接接触的员工.
- 精神残疾人医院的员工被确定为HBV暴露的高风险群体.
研究的目的:
- 调查医院工作人员中HBV感染的程度.
- 评估B型肝炎疫苗在医疗保健工作者中的有效性.
- 为了评估抗体反应,标位下降,以及需要增剂的需要.
主要方法:
- 提供乙型肝炎疫苗接种给与患者直接接触的护士.
- 在接种疫苗后9个月,对500个个体进行了抗体标位测量.
- 对增剂剂量的反应被评估在不响应者和那些度下降的人群中.
主要成果:
- 96%的接种疫苗的工作人员在接种疫苗后9个月内有可检测的抗体.
- 59.4%的人获得了高抗体标位 (>1000 IU/l).
- 女性和年轻人表现出更好的疫苗反应. 抗体标位迅速下降,但强剂恢复了那些初始水平> 100 IU/l 的抗体标位.
结论:
- 乙型肝炎疫苗在诱导高风险医院工作人员的抗体方面非常有效.
- 抗体水平随着时间的推移而下降,这表明需要监测和强剂疫苗接种.
- 召回系统对于管理长期免疫力和预防卫生保健工作者感染HBV是必不可少的.
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