多变体金属有机框架用于调制药物分子的结合和释放
Zhiyue Dong1, Yangzesheng Sun1, Jun Chu1
1Key Laboratory of Biomedical Polymers-Ministry of Education, College of Chemistry and Molecular Sciences, and ‡UC Berkeley-Wuhan University Joint Innovative Center, The Institute of Advanced Studies, Wuhan University , Luojiashan, Wuhan 430072, China.
Journal of the American Chemical Society
|September 13, 2017
概括
我们通过调整孔隙相互作用来编程来自金属有机框架 (MOF) 的客分子释放. 这允许使用功能化MOF进行可预测和可控制的药物输送配置文件.
科学领域:
- 材料科学
- 超分子化学
- 纳米技术
背景情况:
- 控制来自多孔材料的客分子释放对于药物输送等应用至关重要.
- 金属有机框架 (MOF) 提供可调节的孔隙环境,但对释放动力学的精确控制仍然具有挑战性.
研究的目的:
- 通过控制客体孔相互作用来证明可编程的客体分子从功能化MOF释放.
- 建立功能组属性和释放速率常数之间的定量相关性.
- 实现药物释放特征的精确控制和多个分子的同时释放.
主要方法:
- 合成了一系列基于MIL-101 (Fe) 的功能化金属有机框架 (MOF),其中氨基 (-NH2) 和碳酸盐 (-C4H4) 的比例各不相同.
- 从这些MOF中研究了三种探针分子的释放动力学 (ibuprofen, rhodamine B, doxorubicin).
- 与MOF毛孔内的功能组的类型和比例有数量相关的释放速率常数.
主要成果:
- 从MIL-101{\displaystyle {MIL-101}{\displaystyle {MIL-101}}}-{\displaystyle {MIL-101}-{\displaystyle {MIL-101}-{\displaystyle {MIL-101}}-{\displaystyle {MIL-101}-{\displaystyle {MIL-101}-{\displaystyle {MIL-101}-{\displaystyle {MIL-101}-{\displaystyle {MIL-101}-{\displaystyle {MIL-101}-{{\displaystyle {MIL-101}-{\mathrm {NH2}-{x}}}}-{x}}}中获得了32倍的释放速度的调整.
- 在40天的时间内,从MIL-101 (Fe) - (C4H4) x - (NH2) 1 - (x) MOF中将释放峰值时间推移至12天.
- 从单个MOF系统中成功释放了两个亲药物分子 (ibuprofen和 doxorubicin).
结论:
- 通过在功能化MOF中调整客体孔相互作用,可以精确控制客体分子释放配置.
- 与物理混合物或其他多孔材料相比,开发的MOF系统可以更好地控制释放动力学.
- 这种方法使得治疗药物可预测和可编程.
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