离心纤维在远距离视网膜的多巴氨基相互作用细胞上发生突触
1Biological Laboratories, Harvard University, Cambridge, Massachusetts 02138.
Nature
|November 12, 1987
概括
远鱼视网膜中的离心纤维连接到多巴胺细胞,形成中央神经系统对视网膜神经元的影响的途径. 这表明鱼类对视觉处理有广泛的中央控制.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 鱼类生物学 鱼类生物学
背景情况:
- 远鱼具有源自嗅球的离心纤维.
- 这些纤维含有类似FMRFamide和类似露素化激素释放激素 (LHRH) 的.
- 以前对它们的视网膜点和相互作用的理解是有限的.
研究的目的:
- 为了研究离心纤维的精确视网膜终端位置.
- 为了确定离心纤维和视网膜内部神经元之间的关系,特别是多巴胺能交plexiform细胞.
- 阐明中枢神经系统对视网膜处理的影响潜在的视网膜内通路.
主要方法:
- 同时双色免疫标记技术可视化本地化.
- 电子显微镜检查已识别的细胞类型之间的突触接触.
- 在远距离视网膜内神经通路的神经解剖学追踪.
主要成果:
- 离心纤维投射到视网膜的内核和内状层边界.
- 这些纤维经常被附着在多巴氨基相互作用细胞上.
- 观察到离心纤维和多巴胺交错细胞之间的常规突触连接.
结论:
- 离心纤维和视网膜的多巴胺能互细胞之间存在直接的突触连接.
- 多巴胺基互性细胞在水平和双极细胞上发生突触,形成一个网膜内离心通路.
- 所有远端视网膜神经元都可能通过这种新发现的途径受到中央输入的影响.
相关概念视频
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