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在ZATT (ZNF451) 中介的DNA-蛋白交叉链的解析

Matthew J Schellenberg1, Jenna Ariel Lieberman2, Andrés Herrero-Ruiz2

  • 1Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences (NIEHS), Research Triangle Park, NC 27709, USA.

Science (New York, N.Y.)
|September 16, 2017
PubMed
概括

SUMO酶ZATT通过促进TDP2在停滞的TOP2裂变复合体上的活性来解决DNA-蛋白交叉链接. 这种SUMO2调节的通路直接解决了TOP2cc的损伤.

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