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相关概念视频

T Cell Activation and Clonal Selection01:22

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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Mitochondrial precursors are partially unfolded or loosely folded polypeptide chains. Newly synthesized precursors are inhibited from spontaneously folding into their native conformation by the cytosolic chaperones, heat shock proteins 70 (Hsp70), and mitochondrial import stimulation factors (MSFs). Precursors bound to MSFs are guided to the TOM70-TOM37 receptors, while precursors bound to Hsp70  chaperones are targetted to TOM20-TOM22 receptor complexes.
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相关实验视频

Updated: Feb 22, 2026

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
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通过CD28进行线粒体初始化

Ramon I Klein Geltink1, David O'Sullivan1, Mauro Corrado1

  • 1Department of Immunometabolism, Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany.

Cell
|September 19, 2017
PubMed
概括
此摘要是机器生成的。

通过增强线粒体功能和代谢能力,CD28信号传递对于产生有效的记忆T细胞至关重要. 如果没有CD28,T细胞会变得无敏,无法对二次抗原反应.

关键词:
CD28 其他CD8 T 细胞标题1a采用细胞免疫疗法其他类型记忆T细胞没有.线粒体晶体重塑线粒体形态备用呼吸能力

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科学领域:

  • 免疫学
  • 细胞代谢
  • 线粒体生物学

背景情况:

  • 没有CD28协同刺激的T细胞受体 (TCR) 信号产生无能记忆T细胞.
  • 无能T细胞无法对二次抗原暴露做出反应,从而限制了保护性免疫力.

研究的目的:

  • 研究CD28信号在激活过程中对T细胞的代谢重编程中的作用.
  • 了解早期CD28信号如何影响保护性记忆T细胞的发展.

主要方法:

  • 流细胞测量以评估T细胞激活和记忆形成.
  • 用于测量脂肪酸氧化 (FAO) 和备用呼吸能力 (SRC) 的线粒体测定.
  • 微RNA分析以确定参与CD28信号传递的调节途径.

主要成果:

  • 在细胞分裂之前,CD28信号暂时上调卡尼丁棕转移酶1a (Cpt1a),增强线粒体FAO和SRC.
  • 缺少CD28导致微RNA-33 (miR33) 介导的Cpt1a表达减弱,导致代谢损害.
  • 早期的CD28依赖性线粒体启动对于T细胞晶体重塑,SRC发育以及在重新刺激时快速生成细胞因子至关重要.

结论:

  • 最初的CD28信号对于T细胞线粒体的启动至关重要,建立保护性记忆所需的潜在代谢能力.
  • CD28介导的代谢编程对于能够产生强大的二次反应的功能性记忆T细胞至关重要.