在1型糖尿病中,胰岛素分泌β细胞中的免疫活性α-干扰素
A K Foulis1, M A Farquharson, A Meager
1Department of Pathology, Royal Infirmary, Glasgow.
Lancet (London, England)
|December 19, 1987
概括
1型糖尿病患者经常保留β细胞,经常表达α-干扰素和人类白细胞抗原 (HLA) I类. 这表明慢性病毒感染可能有助于1型糖尿病的发病.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 内分泌学 在内分泌学.
背景情况:
- 1型糖尿病是一种自身免疫性疾病,以β细胞破坏为特征.
- 剩余的β细胞通常在1型糖尿病患者中发现.
- 病毒感染在1型糖尿病发病过程中的作用尚未完全理解.
研究的目的:
- 调查1型糖尿病患者残留β细胞中α-干扰素的存在和含量.
- 探索阿尔法干扰素,人类白细胞抗原 (HLA) I类表达和1型糖尿病之间的关系.
- 评估病毒感染在1型糖尿病中的潜在作用.
主要方法:
- 从1型糖尿病患者的37个胰腺和80个控制胰腺的尸检分析.
- 在胰腺小岛中对α-干扰素和HLA类I抗原进行免疫组合化学染色.
- 阿尔法干扰素存在,HLA类I过度表达和临床数据之间的相关性分析.
主要成果:
- 在37例1型糖尿病胰腺患者中,有34例具有残留β细胞.
- 在这34个β细胞种群中,33个对α-干扰素呈阳性.
- 阿尔法干扰素的存在与小岛的HLA类I过度表达有很强的相关性 (93%对0.4%).
- 很少有对照胰腺显示出显著的β细胞α-干扰素,除了病毒性胰腺炎病例.
结论:
- 在1型糖尿病中的残留β细胞经常表达α-干扰素和HLA类I.
- 这些发现表明病毒感染和1型糖尿病之间存在潜在联系.
- 慢性贝塔病毒细胞感染可能是导致1型糖尿病发病的因素.
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