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The Parathyroid Glands
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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Hormones and Bone Tissue
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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Skeleton and Calcium Homeostasis
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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Bone Remodeling
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Synthesis and Functions of Calcitonin
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Major Hormones and Their Functions
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Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
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甲状腺功能障碍
John P Bilezikian1, Leonardo Bandeira2, Aliya Khan3
1Division of Endocrinology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Lancet (London, England)
|September 20, 2017
概括
这是一种常见的内分泌疾病,涉及高水平和副甲状腺激素. 术可以治愈它,但建议对那些没有接受手术的人进行监测.
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科学领域:
- 内分泌学
- 新陈代谢
- 矿物质疾病
背景情况:
- 初级甲状腺功能障碍是一种影响代谢的常见内分泌疾病.
- 它的特征是高血症和甲状腺前激素水平升高.
- 这种情况通常是由于良性甲状腺组织过度生长,影响单个腺体或多个腺体.
研究的目的:
- 提供一次性甲状腺功能增强症的概述.
- 讨论诊断标准和管理选择.
- 突出更新手术指南和监测策略的重要性.
主要方法:
- 对原发性甲状腺功能障碍的现有文献进行审查.
- 临床特征和生化特征的分析.
- 评估当前的诊断和治疗建议.
主要成果:
- 主要甲状腺增生最常是由单一良性甲状腺腺瘤 (80%) 或多个腺增生 (15-20%) 引起的.
- 这种疾病可能无症状,但会导致骨质损失和结石的风险.
- 一种变体存在,血清是正常的,但甲状腺激素升高.
结论:
- 通过手术切除受影响的甲状腺,
- 选择患者进行手术需要遵守最新的指南.
- 非手术候选人需要定期监测血清和骨密度.
