一个研究结肠的起源
M A Stokes1, K J Moriarty, B N Catchpole
1University Department of Surgery, Hope Hospital, Salford, Manchester, England.
Lancet (London, England)
|January 30, 1988
概括
结肠痛,通常在肠道中经历,与特定肠道段内的压力变化有关. 这项研究阐明了这种不适的特征和位置,提供了对胃肠道疼痛机制的见解.
科学领域:
- 胃肠病学 胃肠病学
- 神经胃肠病学 神经胃肠病学
- 内脏疼痛研究研究
背景情况:
- 是腹痛的常见原因,但其精确的内脏起源和特征仍然不完全理解.
- 了解肠内内事件与感知疼痛之间的关系对于有效管理至关重要.
研究的目的:
- 调查局部肠道事件与疼痛感知,特别是肠之间的关系.
- 为了确定实验诱导的肠道疼痛的空间 (位置,长度) 和时间 (持续时间) 特性.
主要方法:
- 在1名正常志愿者和12名患有肠道疾病的患者中,通过气球膨胀和在各种肠道部位注射盐水,诱导轻度的阶段性疼痛.
- 在整个研究过程中,持续记录了内压力.
- 参与者报告了与压力变化相关的疼痛经历.
主要成果:
- 只有当压力上升发生在长度为632厘米的肠段时,才会感觉到疼痛.
- 疼痛的压力上升往往低于非疼痛的局部升高.
- 诱导的阶段性疼痛表现出肠的特征,通常在小肠和大肠持续不到一分钟.
结论:
- 肠道疼痛,模仿肠,与特定肠道段内的压力波动有关.
- 受影响的肠段的长度和压力变化的特征是疼痛感知的关键因素.
- 疼痛发作通常发生在半中心部,并以日益严重的程度扩散到中线.
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