另一个试验失败了
C C Cook1, T D Scannell, M S Lipsedge
1Department of Psychiatry, United Medical School, Guy's Hospital, London.
Lancet (London, England)
|March 5, 1988
概括
这项使用克洛尼丁和洛菲西丁进行阿片类药物戒断管理的研究因非科学问题而被终止. 这些挑战凸显了进行成治疗临床试验的实际困难.
科学领域:
- 药理学 药理学是指药理学的学科.
- 临床研究 临床研究
- 成 药物 药物 药物 药物
背景情况:
- 对阿片类药物戒断综合征 (OWS) 的管理至关重要.
- 克隆丁和洛菲克西丁是对OWS的潜在治疗方法.
- 临床试验面临着超越科学价值的多方面的挑战.
研究的目的:
- 为了比较克洛尼丁和洛菲克西丁在治疗OWS中的疗效.
- 识别和记录在试验期间遇到的非科学障碍.
主要方法:
- 一个双盲,比较的临床试验设计.
- 包括患有阿片类药物戒断综合征的患者.
- 克洛尼丁和洛菲克西丁用于症状管理.
主要成果:
- 由于许多非科学障碍,试验过早结束.
- 问题包括研究床位的可用性,患者自我出院,工作人员的态度和后勤问题.
- 洛菲克西丁的商业停产和资金的撤回也导致了终止.
结论:
- 非科学因素对试验的进展和完成产生了重大影响.
- 该研究强调了临床研究对外部,非科学变量的脆弱性.
- 对OWS治疗的进一步研究需要严格的规划,以减轻这种实际挑战.
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