脂肪组织巨源外体miRNA可调节体内和体外胰岛素敏感性
Wei Ying1, Matthew Riopel1, Gautam Bandyopadhyay1
1Division of Endocrinology and Metabolism, Department of Medicine, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Cell
|September 26, 2017
概括
脂肪组织巨细胞在外体内分泌微RNA (miRNA),影响葡萄糖代谢. 针对这些外体miRNAs为胰岛素抵抗和代谢障碍提供了潜在的治疗策略.
科学领域:
- 代谢疾病研究
- 细胞和分子生物学
- 内分泌学
背景情况:
- 微RNAs (miRNAs) 是基因表达的关键调节者.
- 外体是细胞分泌的囊泡,参与细胞间的交流.
- 脂肪组织巨细胞 (ATM) 在与肥胖相关的代谢功能障碍中起作用.
研究的目的:
- 研究来自ATM的外体分泌miRNAs在调节葡萄糖稳态和胰岛素敏感性的作用.
- 确定参与ATM介导的代谢失调的特定miRNA.
主要方法:
- 从肥胖和瘦小鼠的ATM中获得的外体给受试小鼠.
- 在小鼠中对miR-155表达的基因操纵.
- 骨髓移植研究
主要成果:
- 在瘦小鼠中诱导葡萄糖不耐受和胰岛素抵抗.
- 在肥胖小鼠中,瘦身ATM的外基因组改善了葡萄糖耐受性和胰岛素敏感性.
- 骨髓移植部分扭转了这种表型.
结论:
- ATM 分泌含有miRNA的外体,这些外体作为信号分子来调节全身葡萄糖平衡.
- 外体miRNAs,特别是miR-155,是肥胖症中ATM驱动的胰岛素抵抗的关键媒介.
- 针对外体miRNAs为代谢疾病提供了潜在的治疗途径.
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