对于目标导向的运动技能,皮质脊柱回路的解构
Xuhua Wang1, Yuanyuan Liu1, Xinjian Li2
1F.M. Kirby Neurobiology Center, Boston Children's Hospital and Department of Neurology, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA.
Cell
|September 26, 2017
概括
空间组织的皮质脊髓神经元 (CSN) 控制小鼠前肢运动的不同方面. 这些神经元组连续激活,以管理在运动任务中达到,抓取和过渡步骤.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 计算神经科学是一种神经科学.
背景情况:
- 皮质脊髓神经元 (CSN) 对于运动控制至关重要,它们从皮质传递信号到脊髓.
- 在复杂的运动任务中控制CSN功能的组织原则在很大程度上仍未被定义.
研究的目的:
- 阐明CSN在熟练前肢运动任务中的组织原则.
- 确定区域特定的CSN在食品颗粒检索任务的不同阶段的作用.
主要方法:
- 在小鼠中使用逆行标签系统来识别和研究CSN.
- 进行体内成像,在熟练执行前肢任务时监测CSN活动.
- 采用特定区域的基因操纵来评估不同CSN种群的功能贡献.
主要成果:
- 在执行任务期间,CSN活动表现出地形组织的功能合集的顺序激活.
- 来自尾部前肢区域的CSN对于达到至关重要,而面部CSN对于抓取至关重要.
- 尾部和面部CSN都是必要的过渡式发射运动.
- 特定区域的CSN被投射到不同的脊柱水平,准参与特定任务阶段的前运动神经元.
结论:
- 空间定义的CSN组为熟练的运动编码不同的电机模块.
- 这种空间组织为平行皮质脊髓电路提供了一个框架,用于编排复杂的运动技能.
- 研究结果显示,前肢控制的皮质脊柱管内有一个精确的体质组织.
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