吸入烟雾和肺气
A G Davison1, P M Fayers, A J Taylor
1Cardiothoracic Institute, Brompton Hospital, London.
Lancet (London, England)
|March 26, 1988
概括
在铜合金制造业中对的职业暴露与肺功能异常和肺气有关. 肺功能下降,特别是转移系数 (KCO),随着暴露的增加而恶化.
科学领域:
- 职业医学 职业医学是专业的.
- 肺部医学 肺部医学
- 毒理学 毒理学 毒理学
背景情况:
- 工业环境中的暴露对呼吸系统健康构成风险.
- 铜合金制造涉及潜在的吸入粉尘.
- 以前的研究表明,与肺部疾病之间存在联系.
研究的目的:
- 评估职业暴露对肺功能和胸部X射线图的影响.
- 调查累积暴露与呼吸系统异常之间的关系.
- 为了确定引起的肺损伤是否存在值.
主要方法:
- 在101名铜合金工人和一个匹配的参考组之间,肺功能和胸部放射图的比较.
- 基于估计的累积暴露和测量肝的基础上对工人进行分类.
- 线性回归分析,以评估KCO和累积暴露之间的关系.
主要成果:
- 工人表现出明显更多的肺功能异常和与肺气相一致的放射性变化.
- 肺功能异常在累积暴露或肝脏含量最高的个体中最为明显.
- 在降低KCO和增加累积暴露之间观察到线性关系,没有证据表明安全值.
结论:
- 职业暴露与功能和放射学证据的肺气有关.
- 观察到的肺功能下降,特别是KCO,随着累积暴露而增加.
- 目前英国的职业暴露限值可能不够保护肺发育.
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