通过曲率控制双极方向:芳香折叠体曲β-板和螺旋板-螺旋架构
Arthur Lamouroux1, Laure Sebaoun1, Barbara Wicher1
1Université de Bordeaux, CNRS, Bordeaux Institut National Polytechnique, CBMN (UMR 5248) , Institut Européen de Chimie Biologie, 2 Rue Escarpit, 33600 Pessac, France.
Journal of the American Chemical Society
|October 3, 2017
概括
研究人员创建了具有曲芳香板的新型折叠板,形成独特的篮形螺旋转螺旋结构. 这些结构可以控制客体的结合和释放,与传统的螺旋不同.
科学领域:
- 超分子化学
- 有机化学
- 聚合物科学
背景情况:
- 像和核酸这样的生物聚合物采用常见的折叠结构 (螺旋,转,β-链).
- 具有芳香环的折叠材料提供了超越自然生物聚合物的独特形状可能性.
- 探索新的折叠器架构是获取新功能分子对象的关键.
研究的目的:
- 研究将诱导曲的构建块纳入芳胺β片的效果.
- 合成和表征新的折叠机序列与曲的纸板图案.
- 设计和评估用于受控客户互动的螺旋板螺旋架构.
主要方法:
- 循环和多回合非循环折叠机序列的合成.
- 使用溶液状态和固态状态技术进行结构性表征.
- 用于研究客体结合动力学的NMR光谱.
主要成果:
- 在化溶剂中观察到稳定的曲板形状,克服静电排斥.
- 形成了精确的螺旋转螺旋架构,整合了螺旋和曲的板块.
- 这些篮形结构具有可调节的腔,可控制客体的结合和释放.
结论:
- 有曲的芳香β-片的折叠体可以形成独特,稳定的篮形螺旋-片-螺旋结构.
- 这些新型结构在控制客体结合和释放动力学方面比螺旋具有优势.
- 这些发现为设计具有定制性质的功能性超分子材料开辟了新的途径.
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