帕尔瓦胺和索马托斯塔丁内部神经元控制介质内腔皮层的不同空间编码网络
Chenglin Miao1, Qichen Cao1, May-Britt Moser1
1Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Olav Kyrres Gate 9, MTFS, 7489 Trondheim, Norway.
Cell
|October 3, 2017
概括
沉默帕瓦胺 (PV) 内神经元会破坏中枢内皮层 (MEC) 中的网格细胞模式. 索马托斯坦 (SOM) 内部神经元沉默会损害无周期性发射场的细胞,从而揭示出它们在空间编码中的不同作用.
科学领域:
- 神经科学
- 计算神经科学
- 系统神经科学
背景情况:
- 中间内皮层 (MEC) 对于空间导航至关重要.
- 包括帕瓦胺 (PV) 和体静止素 (SOM) 类型在内的GABAergic内部神经元是MEC电路的关键组成部分.
- 这些内部神经元类在MEC空间表示中的特定作用尚未完全理解.
研究的目的:
- 调查PV和SOM表达内部神经元对MEC空间编码的不同贡献.
- 阐明基底细胞激发和其他空间调节活动模式的细胞机制.
主要方法:
- 使用药物遗传方法在自由运动的小鼠中选择性地静止PV或SOM内部神经元.
- 在空间导航任务中使用电生理学记录神经元活动.
- 分析了内部神经元沉默对电网细胞,速度细胞和非周期性发射场的细胞的影响.
主要成果:
- 沉默光伏内部神经元破坏了MEC电网细胞的六角空间选择性,特别是在II层,并损害了速度细胞调制.
- 沉默SOM内部神经元没有影响网格或速度细胞,但降低了无周期性发射场的细胞的空间选择性.
- 无论是PV还是SOM内部神经元沉默都没有影响边界细胞或头部方向细胞.
结论:
- 在MEC中塑造空间表征时,PV和SOM内部神经元扮演着不同的,不重叠的角色.
- 光伏内部神经元对于电网细胞的周期性点火模式和速度调节至关重要.
- 在其他MEC细胞类型中观察到的无周期空间编码中涉及SOM内部神经元.
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