哺乳动物视网膜中绝对光强度的种群表示
Elliott Scott Milner1, Michael Tri Hoang Do1
1F.M. Kirby Neurobiology Center and Department of Neurology, Boston Children's Hospital and Harvard Medical School, Center for Life Science 12061, Boston, MA 02115, USA; Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Cell
|October 3, 2017
概括
单个M1ipRGC在狭窄的范围内追踪光强度,但它们的群体总体覆盖日光到月光. 内部去极化块可以灵活有效地编码刺激强度.
科学领域:
- 神经科学
- 光生物学
- 细胞生理学
背景情况:
- 环境光线强度对于昼夜节律,兴奋和荷尔蒙调节至关重要.
- 对于光强度的编码神经机制,
- M1内在光敏感的视网膜细胞 (ipRGC) 是哺乳动物中强度驱动功能的关键光受体.
研究的目的:
- 调查单个M1ipRGC及其群体如何表示光强度.
- 探索脱极化块在M1 ipRGC函数中的作用.
- 了解M1 ipRGC在不同光线水平上的编码能力.
主要方法:
- 单个M1ipRGC的电生理记录.
- 对M1ipRGC群体对不同光强度的反应进行分析.
- 研究脱极化块动力学和轴突传播.
主要成果:
- 单个M1ipRGC在有限的强度范围内运行,主要是由于内在去极化阻断.
- M1 ipRGC 群体集体编码的光强度从月光到全日光.
- 脱极化块的动态有助于灵活和高效的群体级光强度编码.
- 轴突传播在脱极化阻断期间调整扭曲的尖峰.
结论:
- M1 ipRGCs不均地跟踪强度;相反,群体动态是宽光编码的关键.
- 内在去极化阻断是一种功能机制,而不仅仅是病态状态,使光强度的表现强大.
- 这种细胞和种群级编码策略允许精确调节依赖光的生理过程.
相关概念视频
Photoreceptors and Visual Pathways
9.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
9.5K
Anatomy of the Eyeball
10.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
10.1K
The Retina
77.0K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
77.0K


