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抗血栓药物使用与血相关并发症之间的关联
Christopher J D Wallis1,2, Tristan Juvet1, Yuna Lee3
1Division of Urology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, Ontario, Canada.
JAMA
|October 4, 2017
概括
抗血栓药物显著增加了老年人患出血相关并发症的风险. 这包括更高的急诊室访问率,住院率,以及严重血液流失的泌尿外科手术.
科学领域:
- 老年医学
- 药理学
- 尿道病学
背景情况:
- 抗血栓药物被广泛用于预防血栓事件.
- 血是一种潜在的并发症,需要进一步了解老年人群的相关风险.
研究的目的:
- 研究抗血栓药物使用与老年人血栓相关并发症之间的关联.
- 量化这些并发症的发病率与抗血栓剂暴露相关.
主要方法:
- 在加拿大安大略省进行了以人口为基础的回顾性队列研究.
- 包括2002年至2014年66岁及以上的公民,分析口服抗凝剂或抗血小板剂的使用情况.
- 血相关并发症被定义为急诊室的访问,住院,或大血的泌尿器科手术.
主要成果:
- 这项研究分析了2,518,064名患者,其中808,897人接受了抗血栓剂.
- 与未暴露的患者相比,服用抗血栓剂的患者患血栓相关并发症的发生率显著更高 (123. 95例/1000人/年).
- 暴露组的泌尿外科手术,住院和急诊诊所的并发症率较高. 服用抗凝血剂和抗血小板剂的人群风险最高 (191.61例/1000人/年).
结论:
- 在老年人中使用抗血栓药物会显著增加血相关并发症的风险.
- 这些发现凸显了对处方抗血栓治疗的老年患者血栓监测的重要性.
- 这项研究表明抗血栓使用与随后的膀癌诊断之间存在潜在联系.
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