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Updated: Feb 21, 2026

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癌症药物成是由ERK2依赖的表型开关传递的

Xiangjun Kong1, Thomas Kuilman1, Aida Shahrabi1

  • 1Division of Molecular Oncology and Immunology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.

Nature
|October 5, 2017
PubMed
概括

对BRAF抑制剂成的癌细胞利用了涉及ERK2,JUNB和FRA1的途径. 破坏这一途径,包括MITF关闭,可以在治疗停止时防止细胞死亡,为耐药癌症提供新的治疗策略.

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