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Updated: Aug 3, 2026

Loss- and Gain-of-function Approach to Investigate Early Cell Fate Determinants in Preimplantation Mouse Embryos
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在海马神经元中表达β神经生长因子基因

C Ayer-LeLievre1, L Olson, T Ebendal

  • 1Department of Medical Chemistry, Karolinska Institutet, Stockholm, Sweden.

Science (New York, N.Y.)
|June 3, 1988
PubMed
概括

神经生长因子 (NGF) 传递 RNA 是由老鼠和小鼠大脑中的神经元合成的,特别是在海马中. 神经元死亡导致NGFmRNA的损失,这表明神经元对神经元的信号传递.

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Determination01:51

Determination

During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...