经确认的孕期孕产妇母性红疹的结果
G Enders1, U Nickerl-Pacher, E Miller
1Institut für Medizinische Virologie und Infektionsepidemiologie, Stuttgart, Federal Republic of Germany.
Lancet (London, England)
|June 25, 1988
概括
在最后一次月经周期 (LMP) 后12天之前的母性红疹感染对胎儿造成的风险最小. 然而,LMP后3-6周发生的红疹显著增加了子宫内感染和先天性红疹综合征的风险.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 儿科 儿科 儿科
背景情况:
- 怀孕期间的红疹感染可能导致严重的胎儿并发症.
- 了解与最后一次月经周期 (LMP) 相比,母亲红疹感染的时间对于评估胎儿风险至关重要.
研究的目的:
- 根据与LMP相关的母体皮疹发病时间来前性评估子宫内红疹感染的风险.
- 确定母性红疹发病时间和胎儿后果之间的相关性,包括先天性红疹综合征.
主要方法:
- 61名怀孕妇女的前性随访,确认红疹发生在LMP前5周至6周后.
- 在39个案例中,终止怀孕和检查胎儿组织是否有红疹病毒.
- 带血清检测特定IgM抗体在22例到期的患者中.
主要成果:
- 在LMP之前或在LMP后11天内出现母性皮疹时,没有检测到子宫内感染.
- 胎儿感染最早发生在LMP.12天后.
- 在LMP发病3-6周后,所有10次怀孕都出现了皮疹发作,导致胎儿感染;4名按期出生的婴儿有先天性损伤.
结论:
- 在LMP发生之前或之后不久发生的红疹感染对胎儿感染的风险是可以忽略不计的.
- 在LMP后3-6周内发生的母性红疹感染具有高胎儿感染和先天异常的高风险.
- 及时评估母乳风疹暴露时间对于管理高风险怀孕至关重要.
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