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缺血性心脏中的空间基因分析:纤维细胞的SOX

Hadi Khalil1, Marjorie Maillet1, Jeffery D Molkentin2

  • 1From Department of Pediatrics, University of Cincinnati (H.K., M.M., J.D.M.), and Howard Hughes Medical Institute (J.D.M.), Cincinnati Children's Hospital Medical Center, OH.

Circulation
|October 11, 2017
PubMed
概括

No abstract available in PubMed .

关键词:
编辑纤维细胞心脏衰竭mRNA 分析转录系数

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Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...